| Eastern Conference | Jo | Pts | Gols | Dif | V | E | D | |
|---|---|---|---|---|---|---|---|---|
| 1. | Inter Miami CF | 34 | 74 | 79:49 | 30 | 22 | 8 | 4 |
| 2. | Columbus Crew | 34 | 66 | 72:40 | 32 | 19 | 9 | 6 |
| 3. | Cincinnati FC | 34 | 59 | 58:48 | 10 | 18 | 5 | 11 |
| 4. | Orlando City | 34 | 52 | 59:50 | 9 | 15 | 7 | 12 |
| 5. | Charlotte FC | 34 | 51 | 46:37 | 9 | 14 | 9 | 11 |
| 6. | New York City FC | 34 | 50 | 54:49 | 5 | 14 | 8 | 12 |
| 7. | New York Red Bulls | 34 | 47 | 55:50 | 5 | 11 | 14 | 9 |
| 8. | CF Montreal | 34 | 43 | 48:64 | -16 | 11 | 10 | 13 |
| 9. | Atlanta United FC | 34 | 40 | 46:49 | -3 | 10 | 10 | 14 |
| 10. | DC United | 34 | 40 | 52:70 | -18 | 10 | 10 | 14 |
| 11. | Philadelphia Union | 34 | 37 | 62:55 | 7 | 9 | 10 | 15 |
| 12. | Toronto FC | 34 | 37 | 40:61 | -21 | 11 | 4 | 19 |
| 13. | Nashville SC | 34 | 36 | 38:54 | -16 | 9 | 9 | 16 |
| 14. | New England Revolution | 34 | 31 | 37:74 | -37 | 9 | 4 | 21 |
| 15. | Chicago Fire | 34 | 30 | 40:62 | -22 | 7 | 9 | 18 |
| Western Conference | Jo | Pts | Gols | Dif | V | E | D | |
|---|---|---|---|---|---|---|---|---|
| 1. | Los Angeles FC | 34 | 64 | 63:43 | 20 | 19 | 7 | 8 |
| 2. | Los Angeles Galaxy | 34 | 64 | 69:50 | 19 | 19 | 7 | 8 |
| 3. | Real Salt Lake | 34 | 59 | 65:48 | 17 | 16 | 11 | 7 |
| 4. | Seattle Sounders | 34 | 57 | 51:35 | 16 | 16 | 9 | 9 |
| 5. | Houston Dynamo | 34 | 54 | 47:39 | 8 | 15 | 9 | 10 |
| 6. | Minnesota United FC | 34 | 52 | 58:49 | 9 | 15 | 7 | 12 |
| 7. | Colorado Rapids | 34 | 50 | 61:60 | 1 | 15 | 5 | 14 |
| 8. | Portland Timbers | 34 | 47 | 65:56 | 9 | 12 | 11 | 11 |
| 9. | Vancouver Whitecaps | 34 | 47 | 52:49 | 3 | 13 | 8 | 13 |
| 10. | Austin FC | 34 | 42 | 39:48 | -9 | 11 | 9 | 14 |
| 11. | FC Dallas | 34 | 41 | 54:56 | -2 | 11 | 8 | 15 |
| 12. | St. Louis City SC | 34 | 37 | 50:63 | -13 | 8 | 13 | 13 |
| 13. | Sporting Kansas City | 34 | 31 | 51:66 | -15 | 8 | 7 | 19 |
| 14. | San Jose Earthquakes | 34 | 21 | 41:78 | -37 | 6 | 3 | 25 |